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| 货号： | IMA1015-0005MG |
| 保存条件： | -20℃ |
| CAS号： | 193551-21-2 |
| 供应商： | 上海伟进生物科技有限公司 |
| 数量： | 50 |
| 英文名： | SB 239063 |
| 保质期： | 2 years |
| 规格： | 5mg |
Biological Activity
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SB 239063 is a highly potent and selective inhibitor of p38 MAP kinase with IC50 value of 44 nM.The compound exibits equipotent inhibitory activity against α- and β- isoform, and no activity (up to 100 μM) against the γ- and δ-kinase isoforms. In LPS-stimulated human PBMCs, SB 239063 suppresses IL-1 and TNF-α production (IC50 = 0.12 and 0.35 μM, respectively).SB 239063 acts as a potent inhibitor of inflammatory cytokine production, inhibits eosinophil recruitment, in addition to enhancing apoptosis of these cells. SB 239063 may be a potential therapeutic for the treatment of asthma and other inflammatory disorders [1].As a second-generation p38 MAPK inhibitor, SB 239063 displays improved kinase selectivity and increased cellular (3-fold) and in vivo (3- to 10-fold) activity over the first-generation inhibitors such as SB 203580. SB 239063 dosed through different routes reduces brain injury and neurological deficits in cerebral focal ischemia [2].
Chemical Properties
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| Cas No.: 193551-21-2 | M. Wt.: 368.41 |
| Formula: C20H21FN4O2 | Purity: ≥98% (HPLC) |
| Chemical Name: trans-1-(4-hydroxycyclohexyl) -4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole | |
| Appearance: White solid | |
| Solubility：Soluble to 10 mM in DMSO with slight warming to achieve full solubilization. | |
| Storage：Store desiccated at -20 ºC for the stability up to two years, prevent from light. | |
Application Concentration (Just for reference)
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The appropriate working concentration of SB 239063 depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use.
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