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份 库存999份
| 货号： | ISH1021-0001MG |
| 保存条件： | -20℃ |
| CAS号： | 483367-10-8 |
| 供应商： | 上海伟进生物科技有限公司 |
| 数量： | 10 |
| 英文名： | Purmorphamine |
| 保质期： | 2 years |
| 规格： | 1mg |
Biological Activity
Purmorphamine is a 2,6,9-trisubstituted purine compound that selectively induces osteogenesis in multipotent mesenchymal progenitor cells. The small molecule Purmorphamine has been found to activate Hedgehog (Hh) signaling pathway by directly targeting Smoothened (Smo), resulting in the up- and down-regulation of its downstream target genes, including Gli1 and Patched. The EC50 of purmorphamine for differentiation of C3H10T1/2 cells based on alkaline phosphatase (ALP) expression is 1 µM. This compound may ultimately be useful for the treatment of bone-related disease and neurodegenerative disease [1-3]. Purmorphamine can replace sonic hedgehog (SHH) in the entire process of ventral spinal progenitor specification and motor neuron differentiation with a similar efficiency [4].
Chemical Properties
| Cas No.: 483367-10-8 | M. Wt.: 520.62 |
| Formula: C31H32N6O2 | Purity: >98% |
| Chemical Name: 9-cyclohexyl-N-(4-morpholin-4-ylphenyl)-2-naphthalen-1-yloxypurin-6-amine | |
| Appearance: White to off-white solid | |
| Solubility: Soluble in DMSO up to 50 mM | |
| Storage: Store powder at +4 ºC desiccated. Following reconstitution, aliquot and freeze at -20 ºC, prevent from repeated freeze/thaw cycles. | |
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