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| 货号： | ITB1001-0010MG |
| 保存条件： | -20℃ |
| CAS号： | 301836-41-9 |
| 供应商： | 上海伟进生物科技有限公司 |
| 数量： | 10 |
| 英文名： | SB431542 |
| 保质期： | 2 years |
| 规格： | 10mg |
Biological Activity
SB 431542 is a potent and selective inhibitor of the TGF-β type I receptor activin receptor-like kinases ALK5 (IC50 = 94 nM) [1], ALK4 (IC50 = 140 nM) [2] and ALK7, but has no effects on the more divergent ALK family members (ALK1/ALK2 and ALK3/ALK6) that recognize bone morphogenetic proteins (BMPs). SB 431542 specifically suppresses the ability of activated ALK4, ALK5, and ALK7 to induce both Smad2/Smad4- and Smad3/Smad4-dependent transcription [3]. SB 431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells [4]. Activation of Smad2/3 is not only required for maintenance of the undifferentiated state in hESCs and the formation of embryoid bodies, but is necessary for the maintenance of pluripotency in the ICM of mouse blastocyst outgrowths. The phosphorylation of Smad2/3 can be completely inhibited by SB 431542 [5]. This compound also provides a novel therapy for malignant gliomas by reducing cell proliferation, angiogenesis, and motility [6].
Chemical Properties
| Cas No.: 301836-41-9 | M. Wt.: 384.39 |
| Formula: C22H16N4O3 | Purity: >99% |
| Chemical Name: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide | |
| Synonym: SB-431542, SB431542 | |
| Appearance: A crystalline solid | |
| Solubility: Soluble in DMSO (75 mg/mL) and ethanol (40 mg/mL).Very sparingly soluble in water (< 1mg/mL). | |
| Storage: Store solid at -20°C for the stability of 2 years, protect from light. Following reconstitution, aliquot and freeze at -20°C, prevent from repeat freeze/thaw cycles. | |
Application Concentration (Just for reference)
The appropriate working concentration of SB 431542 depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use
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