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份 库存999份
| 货号： | IL6-S183HR |
| 供应商： | 北京孚博 |
| 数量： | 100 |
| 规格： | 20ug;50ug/大包装请询价 |
Interleukin-6 (IL-6) is a multifunctional protein that plays important roles in host defense, acute phase reactions, immune responses, and hematopoiesis. According to the type of biological responses being studied, IL-6 was previously named interferon-b2, 26 kDa protein, B cell stimulatory factor-2 (BSF-2), hybridoma/plasmacytoma growth factor, hepatocyte stimulating factor, cytotoxic T cell differentiation factor, and macrophage-granulocyte inducing factor 2A (MGI-2A). The IL-6 designation was adopted after these variously named proteins were found to be identical on the basis of their amino acid and/or nucleotide sequences. IL-6 is expressed by a variety of normal and transformed cells including T cells, B cells, monocytes/macrophages, fibroblasts, hepatocytes, keratinocytes, astrocytes, vascular endothelial cells, and various tumor cells. The production of IL-6 is upregulated by numerous signals including mitogenic or antigenic stimulation, LPS, calcium ionophore, IL-1, IL-2, IFN, TNF, PDGF, and viruses. IL-6 expression in monocytes is inhibited by IL-4 and IL-13.
Source: Escherichia Coli
Species: Human
Unit: 1 mg
Molecular Weight: Approximately 20.7 kDa, a single non-glycosylated polypeptide chain containing 183 amino acids.
Biological Activity: The ED50 determined by a cell proliferation assay using IL-6-dependent murine 7TD1 cells is less than 0.1 ng/mL, corresponding to a specific activity of > 1.0 × 107 IU/mg.
Purity: > 95% by SDS-PAGE and HPLC analyses.
Endotoxin: Less than 1 EU/mg of IL-6 as determined by LAL method.
AA Sequence:
VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE
SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL
QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL
QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM
Formulation: Lyophilized from a 0.2 mm filtered concentrated solution in PBS, pH 7.4.
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.
Physical Appearance: Sterile filtered white lyophilized (freeze-dried) powder.
Storage: Recombinant IL6 although stable at 2-8°C for 1 week, should be stored below -20°C for long term storage. Please prevent freeze thaw cycles.
Usage: FOR RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
温馨提示：不可用于临床治疗。
[VIP第1年] 指数:2
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