分子量:55 kDa纯度:>95% as determined by SDS-PAGE.内毒素:Less than 1.0 EU per μg of the Human YWHAB, GST Tag by the LAL method.Buffer:50 mM Tris, 150 mM NaCl, pH 7.4生物活性:产品特性:Human YWHAB, GST Tag is fused with a GST tag at the N-terminus, and has a calculated MW of 55 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 53 kDa in SDS-PAGE .产品背景:Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (YWHAB) is also known as 14-3-3 protein beta, GW128, HS1. YWHAB belongs to the 14-3-3 family. YWHAB binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. YWHAB is negative regulator of osteogenesis. YWHAB blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
SDS-PAGE
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