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| 货号： | YB-4180 |
| 生长状态： | 贴壁生长 |
| 年限： | 见说明书 |
| 运输方式： | 干冰运输or活细胞运输 |
| 器官来源： | 见说明书 |
| 是否是肿瘤细胞： | 见说明书 |
| 细胞形态： | 上皮样；多角形 |
| 免疫类型： | 请咨询销售人员 |
| 物种来源： | 人、大鼠、小鼠、、、、 |
| 组织来源： | 见说明书 |
| ATCC Number： | 详见官方网站 |
| 细胞类型： | 复苏 |
| 供应商： | 钰博生物 |
| 数量： | 大量 |
Synonyms AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGFBR-2, TGF-beta receptor type-2, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFBR2.
Introduction TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.
Patent Rights The sale and/or commercial use of Recombinant Human Transforming Growth Factor Beta Receptor II (TGFBR2) is prohibited in the United States of America (U.S.A).
Recombinant Human Transforming Growth Factor Beta Receptor IIDescription TGFBR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids (27-159 a.a.), the extracellular domain of TGFBR2, having a molecular mass of 15.1 kDa.
TGFBR2 is purified by proprietary chromatographic techniques
Source Escherichia Coli.
Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation Lyophilized from a 0.2 μm filtered solution in buffer containing 150mM NaCl & 50mM sodium phosphate buffer pH-7.5.
Recombinant Human Transforming Growth Factor Beta Receptor IISolubility It is recommended to reconstitute the lyophilized TGFBR2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability Lyophilized TGFBR2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TGFBR2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity Greater than 97.0% as determined by SDS-PAGE.
Activity In ELISA assay, concentrations 0.5-1µg/ml can be used for TGF-beta measurements
Amino Acid Sequence HVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPD
Recombinant Human Transforming Growth Factor Beta Receptor IIUsage CHI's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. 
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