Anti-DCUN1D1抗体

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单价: 1380.00
品牌: Ybscience
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更新: 2020-10-23
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 Anti-DCUN1D1抗体

产品编号 YB-14306R
英文名称 DCUN1D1
中文名称 鳞状细胞癌相关蛋白抗体
别    名 DCN1 defective in cullin neddylation 1 domain containing 1; DCN1 like protein 1; DCNL1; DCNL1_HUMAN; DCUN1 domain containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1 like protein 1; RP 42; RP42; RP42 homolog; SCCRO; SCRO; Squamous cell carcinoma related oncogene; Tes 3; Tes3.  
规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 100ul  200ul
研究领域 肿瘤  细胞生物  肿瘤细胞生物标志物  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Chicken, Cow, Horse, 
产品应用 WB=1:500-2000 ELISA=1:500-1000   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
细胞定位 细胞核 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCUN1D1:1-100/259 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background: DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.  SWISS: Q96GG9  Gene ID: 54165 Database links:

Entrez Gene: 54165 Human

Entrez Gene: 424963 Chicken

Entrez Gene: 539869 Cow

Entrez Gene: 114893 Mouse

Entrez Gene: 327232 Zebrafish

Omim: 605905 Human

SwissProt: Q5ZKU1 Chicken

SwissProt: Q96GG9 Human

SwissProt: Q9QZ73 Mouse

Unigene: 104613 Human

Unigene: 374810 Mouse

Unigene: 379305 Mouse

Unigene: 474495 Mouse

Unigene: 113807 Zebrafish

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.   
产品图片
Sample: Epithelium (Mouse) Lysate at 40 ug Primary: Anti-DCUN1D1 (bs-14306R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 30 kD