点击图片查看原图Rabbit Anti-SOD2/FITC Conjugated antibody
FITC标记的超氧化物歧化酶2抗体
| 英文名称 | Anti-SOD2/FITC |
| 中文名称 | FITC标记的超氧化物歧化酶2抗体 |
| 别 名 | IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; SOD2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 激酶和***酸酶 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | Flow-Cyt=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOD2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Subunit: Homotetramer. Subcellular Location: Mitochondrion matrix. Post-translational modifications: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. DISEASE: Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the iron/manganese superoxide dismutase family. Database links: Entrez Gene: 6648 Human Entrez Gene: 20656 Mouse Entrez Gene: 24787 Rat Omim: 147460 Human SwissProt: P41976 Cow SwissProt: P04179 Human SwissProt: P09671 Mouse SwissProt: P41982 Rabbit SwissProt: P07895 Rat Unigene: 487046 Human Unigene: 290876 Mouse Unigene: 10488 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是铁***超氧化物歧化酶家族的成员。它编码形成同源四聚体的线粒体蛋白，每个亚基结合一个***离子。这种蛋白质与氧化***酸化的超氧化物副产物结合，并将其转化为过氧化氢和双原子氧。该基因的突变与特发性心肌病（IDC）、早衰、散发性运动神经元疾病和癌症有关。编码不同的异构体的交替转录剪接变异体已被表征。[ RefSeq，JUL 2008 ]
