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Anti-LASS4抗体
| 产品编号 | YB-10189R |
| 英文名称 | LASS4 |
| 中文名称 | 长寿相关基因lASS4抗体 |
| 别 名 | CerS4; LAG1 homolog ceramide synthase 4; LAG1 longevity assurance homolog 4; LASS 4; LASS4 LAG1 homolog ceramide synthase 4; Trh 1; Trh1; LASS4_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LASS4:101-200/394 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: LASS4 is a member of the LASS (longevity assurance homologue) family which are involved in determining life span in yeast, by an unknown molecular mechanism. Members of this family are highly conserved from yeasts to mammals. Five mouse and human LASS family members, namely LASS1, LASS2, LASS4, LASS5 and LASS6, have been identified and characterized. LASS proteins are thought to be involved in ceramide synthesis. Overproduction of a single LASS protein results in an increase in one or more specific ceramide species, which differ in fatty-acid chain length. LASS proteins possess specific fatty acyl-CoA preferences, but all can use sphingosine or dihydrosphingosine as the long-chain base substrate. LASS family members exhibit different tissue-specific expression patterns, which may contribute to the production of tissue-specific ceramides. Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. Subcellular Location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane; Multi-pass membrane protein. Similarity: Contains 1 homeobox DNA-binding domain. Contains 1 TLC (TRAM/LAG1/CLN8) domain. SWISS: Q9HA82 Gene ID: 79603 Database links: Entrez Gene: 79603 Human SwissProt: Q9HA82 Human Unigene: 515111 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-LASS4 Polyclonal Antibody, Unconjugated(bs-10189R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
