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- Specification
- Product Description:
- Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Origin:
- Human
- Source:
- Genomic DNA
- Notice:
- We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
- Regulation Status:
- For research use only (RUO)
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Gene Information
- Entrez GeneID:
- 5792
- Gene Name:
- PTPRF
- Gene Alias:
- FLJ43335,FLJ45062,FLJ45567,LAR
- Gene Description:
- protein tyrosine phosphatase, receptor type, F
- Omim ID:
- 179590
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
- Other Designations:
- LCA-homolog,OTTHUMP00000008684,leukocyte antigen-related (LAR) PTP receptor,leukocyte antigen-related tyrosine phosphatase,protein tyrosine phosphatase, receptor type, F polypeptide,receptor-linked protein-tyrosine phosphatase LAR
- Gene Pathway
- Adherens junction
- Cell adhesion molecules (CAMs)
- *** signaling pathway
- Related Disease
- Diabetes Mellitus, Type 2
- *** Resistance
- Obesity
- Obesity
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