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- 性质Recombinant
- 来源E. coli
- 氨基酸序列
- AccessionP05019
- 种属Human
- 序列GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFR SCDLRRLEMYCAPLKPAKSA
- 分子量8 kDa
- 氨基酸49 to 118
技术指标
Our Abpromise guarantee covers the use of ab9573 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 应用
Functional Studies
SDS-PAGE
- 内毒素水平< 0.100 Eu/µg
- 形式Lyophilised
- 补充说明The biological activity is determined by its ability to stimulate the proliferation of mouse FDC-P1 cells. The ED50 was determined by a cell proliferation assay using FDC-P1 cells is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg. Reconstitute in water.
- 浓度由溶解方法决定 由溶解方法决定
制备和贮存
- 稳定性和存储
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
n/a
This product is an active protein and may elicit a biological response in vivo, handle with caution.
- 复溶Reconstitute with 100 ul of deionised water (or equivalent Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
常规信息
- 别名
- IBP1
- IGF I
- IGF IA
see all - 功能The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
- 疾病相关Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
- 序列相似性Belongs to the insulin family.
- 细胞定位Secreted.
