cEPO (human):Fc (human) (rec.) (non-lytic)

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Synonyms : cEPOHost : CHO cellSequence : The extracellular domain of human cEPO(NP_000790.2)(Pro30-Arg193)(Arg103Glu) is fused to the N-terminus of the Fc region of a mutant human IgG1.Molecular Mass: 44KDa (monomer)Non-lytic : Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).Purity : >98%,by SDS-PAGE under reducing conditionsEndotoxin Content : <0.06 EU/μg as determined by LAL test.Activity: Measured by the dose-dependant stimulation of human megakaryoblastic leukemia cells.Formulation : Lyophilized from 0.2 μm-filtered solution in PBS.Reconstitution : Reconstitute at 100 μg/ml in sterile PBS.Use / Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.Avoid freeze/thaw cycles.