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H1N1 NA / Neuraminidase Protein Datasheet
H1N1 NA Protein Price Inquiry ( Available Sizes )
- 大包装: 询价
H1N1 NA蛋白产品信息
别名: NA
表达方式: A DNA sequence encoding the Influenza A virus (A/California/04/2009 (H1N1)) neuraminidase (ACP41107.1) (His 36-Lys 469) was expressed, the cell lysates are collected, and bio-activity was tested
种属: Influenza A Virus H1N1 表达宿主: Human Cells H1N1 NA蛋白质控指标
生物活性:
Measured by its ability to cleave a fluorogenic substrate, 2-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid
The specific activity is > 600,000 pmoles / min / tube
内毒素: < 1.0 EU per μg of the protein as determined by the LAL method 稳定性: Samples are stable for up to twelve months from date of receipt at -70℃ 分子量: The influenza H1N1 virus Neuraminidase comprises 450 amino acids 缓冲液: Lyophilized from sterile PBS , pH 7.4
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
H1N1 NA蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. H1N1 NA蛋白相关产品和研究主题
Related Areas:
Enzyme>>Carbohydrate Metabolism Enzymes>>H1N1 neuraminidase/H1N1 NA
Immunology>>Innate Immunity>>Lysosomal Enzyme>>H1N1 neuraminidase/H1N1 NA
Virus>>Influenza Virus>>H1N1 neuraminidase/H1N1 NA
Proteins:
Products Source (CLICK for detailed Info. and Price) Molecule Description Cat No Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA Fc Tag 11058-V01H Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA His Tag 11058-V07H Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA His Tag 11058-V07B Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA His Tag 11058-V07HC Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA - 11058-VNAHC Protein Influenza Neuraminidase (NA) H1N1, A/California/04/2009 NA - 11058-VNAHC1 Antibodies:
Products Antigen Source (CLICK for detailed Info. and Price) Antigen Molecule Application Cat No MAb Influenza Antibody to H1N1, Mouse Anti H1N1 MAb NA WB, ELISA 11058-MM04 Related Influenza Virus Research Tools
- Influenza Virus Research Tools
- Influenza Neuraminidase & Antibody
- Influenza Neuraminidase (NA) Protein
- H1N1 Neuraminidase
- A/California/04/2009
H1N1 NA蛋白背景综述
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. NA, also called sialidases, specifically catalyze the hydrolysis removal of terminal sialic acid residues from viral and cellular glycoconjugates. It is known that HA binds to the sialic acid-containing receptors on the surface of host cells during initial infection, and at the end of an infectious cycle, NA cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. NA is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell. NA is a single-pass type I I membrane protein which exists as a homotetramer, and the transmembrane domain is involved in lipid raft association during intracellular transport. NA is suggested to play a role in the determination of host range restriction on replication and virulence. Nine subtypes of NA have been identified, and subtypes N1 and N2 have been positively linked to epidemics in man.
参考文献
- Barman, S. et al., 2000, J. Virol. 74: 6538-6545.
- Colman, PM. et al., 1983, Nature. 303: 41-44.
- Suzuki, T. et al., 2005, J. Virol. 79: 11705-11715.
- von, Itzstein, M. 2007, Nat. Rev. Drug. Discov. 6: 967-974.
[VIP第1年] 指数:1
