Catalog Number:
AF-450-32
Synonyms:
Vascular Endothelial Growth, Factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived, endothelial cell mitogen
Description:
VEGF是一种强效促生长和血管生成的细胞因子。它可刺激内皮细胞的增殖和存活，并促进血管生成，增强血管通透性。VEGF表达于血管化组织中，在正常及病理性的血管生成过程中发挥关键作用。大量研究表明，VEGF参与诱导肿瘤转移和眼内新生血管综合征。VEGF信号通过三个受体传递信号，包括fms样酪氨酸激酶(flt-1)，KDR基因产物(KDR的小鼠同源物是flk-1的基因产物)和flt4基因产物。重组小鼠VEGF是分子量为39.0 kDa的同源二聚体蛋白，由两个165个氨基酸的多肽链通二硫键连接而成。生产过程中的所有试剂均为非动物源性。
AA Sequence:
MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml.
Cross Reactivity:
Mouse
Research Interests:
| Angiogenesis/ Cardiovascular | | Cancer |
| Inflammation | | Proliferation |
Country of Origin:
USA
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[VIP第1年] 指数:1
