Catalog Number:
AF-310-13
Synonyms:
B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLys, THANK
Description:
BAFF(B细胞激活因子)是TNF配体家族的一员,表达于T细胞,巨噬细胞,单核细胞和树突状细胞。BAFF参与激活B细胞和T细胞的功能,并且是外周B细胞一个重要的生存和成熟因子。BAFF通过TACI,BCMA和BAFF-R等三种不同的TNF受体传递信号。人类BAFF的基因编码一个含285个氨基酸的II型跨膜蛋白,其含有一个46个氨基酸的胞浆结构域,一个21个氨基酸的跨膜结构域,和一个218个氨基酸的胞外结构域。重组人可溶性BAFF是一个含153个氨基酸的多肽(17.0 kDa的),包含BAFF胞外结构域的TNF样部分。生产过程中所用的所有试剂均为非动物源性。
AA Sequence:
MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL
Source:
E.coli
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.
Cross Reactivity:
Human, Mouse
Research Interests:
| Apoptosis | | Immune System |
| Stem Cells & Differentiation | | TNF Superfamily |
Country of Origin:
USA