产品发布日期：PeproTech 2013年4月

Recombinant Murine G-CSF

Catalog Number:

AF-250-05

Synonyms:

Granulocyte Colony-Stimulating, Factor, CSF-3, MGI-1G, GM-CSFβ, pluripoietin

Description:

G-CSF是一种造血生长因子，可以刺激定向祖细胞向嗜中性粒细胞发育，并且能够增强成熟的终末细胞的功能活性。多种细胞，如巨噬细胞、成纤维细胞、内皮细胞和骨髓基质细胞等在应答特定刺激时均可产生G-CSF。目前临床上G-CSF主要用于骨髓移植后促进患者造血功能的恢复。人和小鼠的G-CSF具有物种交叉反应活性。重组小鼠的G-CSF是分子量为19.0 kDa的蛋白，含179个氨基酸残基。生产过程中的所有试剂均为非动物源性。

AA Sequence:

MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to stimulate the proliferation of mouse M-NFS-60 cells. The expected ED₅₀ is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁷ units/mg.

Cross Reactivity:

Mouse, Rat

Research Interests: