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Disease: Prostatic adenocarcinoma grade IV Origin: Derived from metastatic bone Species: Homo sapiens Tissue: Prostate Morphology: Epithelial Properties: Adherent Cytogenic data: The line is near-triploid Patient: Male, Caucasian, 62 yrs of age Medium: RPMI1640 + 10% FBS Subculture: 1:3 to 1:6 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C Freezing Medium: Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility:Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens:HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Protein Expression: HLA A1, A9 DNA Profile (STR): Amelogenin: X CSF1PO: 11; D13S317: 11; D16S539: 11; D5S818: 13; D7S820: 8,11; THO1: 6,7; TPOX: 8,9; vWA: 17 Mutations in PC-3 Cells Related cells by Organ:PC-3 cells VcaP cells References for PC-3 cells:1. Vyas, H. K., Pal, R., Lohiya, N. K., and Talwar, G. P. A partner monoclonal antibody to Moab 730 kills 100% of DU145 and PC3 androgen-independent cancer cells. J Biosci, 34: 909-916, 2009. 2. Roca, H., Varsos, Z. S., and Pienta, K. J. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia, 11: 1309-1317, 2009. 3. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S., and Diaz-Laviada, I. The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells. J Immunotoxicol, 6: 249-256, 2009. 4. Pei, Z., Li, H., Guo, Y., Jin, Y., and Lin, D. Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Int Immunopharmacol, 10: 50-56. 5. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S., and Diaz-Laviada, I. The cannabinoid R(+)methanandamide induces IL-6 secretion by prostate cancer PC3 cells. J Immunotoxicol, 2009. 6. Chen, J., Xia, D., Luo, J. D., and Wang, P. Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. Asian J Androl, 11: 669-677, 2009. 7. Zhou, Q., Yan, B., Hu, X., Li, X. B., Zhang, J., and Fang, J. Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Mol Cancer Ther, 8: 1684-1691, 2009.
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