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| 货号： | PR-1030 |
| 宿主： | rabbit |
| 保质期： | 2年 |
| 抗原来源： | mouse, |
| 数量： | 大量 |
| 供应商： | 厚普生物 |
| 级别： | 亲和纯化 |
| 是否单克隆： | 否 |
| 抗体英文名： | HMG-CoA reductase antibody |
| 应用范围： | IHC,WB,ICC,IF,IP |
| 保存条件： | 4度 |
| 适应物种： | Human,Rat, Mouse, Rabbit |
| 规格： | 0.2ml |
HMG-CoA reductase Antibody
Catalog Number:PR-1030
Background: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.
Description: Rabbit polyclonal to HMG-CoA reductase
Immunogen: KLH conjugated synthetic peptide derived fromHMG-CoA reductase
Specificity: ·Reacts with Human, Mouse, Hamster and Rat.
·Isotype: IgG
Application: ·Western blotting: 1/500-1000. Predicted Mol wt: 97 kDa;
·Immunohistochemistry (Frozen/paraffin tissue section): 1/100-500;
·Immunocytochemistry: 1/200-500;
·ELISA: 1/500;
· Optimal working dilutions must be determined by the end user.
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