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| 货号： | A4262 |
| 英文名： | Actinomycin D |
| CAS号： | 50-76-0 |
| 供应商： | 广州华剑 |
| 保质期： | 2年 |
| 数量： | 大量 |
| 保存条件： | 2-8℃ |
| 规格： | 2mg |
英文名:Dactinomycin, Actinomycin D, ACTD
中文名:更生霉素,放线菌素D
CAS:50-76-0
说明:放线菌素D（Dactinomycin D）又称更生霉素，分子中含有一个苯氧环结构，通过它连接两个等位的环状肽链。此肽链可与DNA分子的脱氧鸟嘌呤发挥特异性相互作用，使 dactinomycin D嵌入DNA双螺旋的小沟中，与DNA形成复合体，阻碍RNA多聚酶的功能，抑制RNA的合成，特别是mRNA的合成。属于周期非特异性药物。一次静脉注 射给药后，很快从血浆消除，多数药物以原形经胆汁和尿液排出。抗瘤谱较窄，用于肾母细胞瘤、绒毛膜上皮癌、横纹肌肉瘤和神经母细胞瘤等。
Sigma相关产品资料：
SigmaA1410 Actinomycin D from Streptomyces sp.,
~98% (HPLC)
| Synonym: | Actinomycin C1, Actinomycin IV, Dactinomycin |
| CAS Number: | 50-76-0 |
| Linear Formula: | C62H86N12O16 |
| Molecular Weight: | 1255.42 |
| Beilstein Registry Number: | 605235 |
| EC Number: | 200-063-6 |
| MDL number: | MFCD00005033 |
| PubChem Substance ID: | 24890541 |
Description
| Biochem/physiol Actions | An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. |
| Caution | Hygroscopic and light sensitive. |
性质
| biological source | from Streptomyces sp. |
| assay | ~98% (HPLC) |
| form | powder |
| color | red, powder |
|
| red to orange |
| mp | 251-253 |
| solubility | DMSO: 1 mg/mL |
|
| ethanol: soluble |
| storage temp. | 2-8°C |
安全性
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 22-28-36/37-45 |
| RIDADR | UN3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | AU1575000 |
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