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份 库存999份
| 货号： | 2A-11046-5 |
| 数量： | 大量 |
| 规格： | 1mg/5 mg/10mg |
Synonyms NBD-Glucose
Formal Name 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose
CAS Number 186689-07-6
Molecular Formula C12H14N4O8
Purity ≥98% (mixture of α and β)
Stability 2 years
Storage -20°C
2-NBDG is a fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues.1,2 It is also used as a topical contrast reagent for the detection of neoplasia.3,4 2-NBDG can be used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry.5,3,6,7
1 Yoshioka, K., Takahashi, H., Homma, T., et al. A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli. Biochim Biophys Acta 1289(1) 5-9 (1996).
2 Yamada, K., Saito, M., Matsuoka, H., et al. A real-time method of imaging glucose uptake in single, living mammalian cells. Nat Protoc 2(3) 753-763 (2007).
3 Nitin, N., Carlson, A.L., Muldoon, T., et al. Molecular imaging of glucose uptake in oral neoplasia following topical application of fluorescently labeled deoxy-glucose. Int J Cancer 124(11) 1-20 (2009).
4 Thekkek, N., Maru, D.M., Polydorides, A.D., et al. Pre-clinical evaluation of fluorescent deoxyglucose as a topical contrast agent for the detection of Barrett’s-associated neoplasia during confocal imaging. Technol Cancer Res Treat 10(5) 431-441 (2011).
5 Loaiza, A., Porras, O.H., and Barros, L.F. Glutamate triggers rapid glucose transport stimulation in astrocytes as evidenced by real-time confocal microscopy. J Neurosci 23(19) 7337-7342 (2003).
6 Langsner, R.J., Middleton, L.P., Sun, J., et al. Wide-field imaging of fluorescent deoxy-glucose in ex vivo malignant and normal breast tissue. Biomed Opt Express 2(6) 1514-1523 (2011).
7 Berney, M., Weilenmann, H., and Egli, T. Flow-cytometric study of vital cellular functions in Escherichia coli during solar disinfection (SODIS). Microbiology 152 1719-1729 (2006).
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