Crohn's Disease PCR Array 克罗恩病基因表达PCR芯片

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克罗恩病基因表达PCR芯片可用于研究在肠道炎症(IBD)中差异表达的84个基因的表达。在炎症发生和恶化过程中,作为细胞外重构酶的炎症细胞因子,调节免疫反应的T细胞均发挥了重要作用,是研究各种肠道炎症的生物标志物。利用该芯片研究者即能够利用该芯片简单可靠地同时检测肠道炎症相关基因的表达。
Apoptosis: CASP1 (ICE), CCL2 (MCP-1), EGR3, IL1B, IL2RA (CD25), IL6, ITGB2, LCN2 (NGAL), SOD2, TNF.
Inflammation: C3, CCL11 (Eotaxin), CCL2 (MCP-1), CCL20 (MIP-3A), CCL25 (TECK), CCL5 (RANTES), CCR1, CCR2, CCR5, CX3CL1, CXCL1, CXCL10 (INP10), CXCL11 (I-TAC/IP9), CXCL2, CXCL3, CXCL9 (MIG), CXCR1 (IL8RA), FPR1, IL13, IL17A, IL1B, IL2RA (CD25), IL23A, IL5, IL6, IL8, ITGB2, LTB, LYZ, S100A8, S100A9, SAA1, SELE, STAT3, TNF.
Immunity: Humoral: CCL2 (MCP-1), IL6, DEFA5, DEFA6, LYZ.
Innate: C3, C4BPB, CASP1, CD55, CR2, IL1RN, IRF5, ISG15 (G1P2), LCN2 (NGAL), NOD2, NOS2 (iNOS), SAA1, TYK2.
Adaptive: CCL11 (Eotaxin), CCR2, CCR5, CCR9, CXCR3, HLA-DQA1, HLA-DRA, HLA-DRB1, IFNG, IL13, IL17A, IL2RA (CD25), IL5, IL6, IRF5, STAT1.
Adhesion & Remodeling: CCL2 (MCP-1), CCR1, CCL11 (Eotaxin), CSTA, CX3CR1, CXCL12 (SDF1), CXCR3, ITGB2, MMP1, MMP10, MMP3, MMP7, PECAM1, SELE, SELL (LECAM1), TIMP1, VWF.
Unfolded Protein Response: HSP90B1 (TRA1), HSPA5 (GRP78), UBD.
Digestive
Secreted Proteins: GCG, MUC1, REG1A, REG1B, TFF1 (pS2).
Metabolism: ALDOB, PCK1, TDO2.
Other Genes: ABCB1 (MDR1), ATG16L1, CHI3L1, EDN3, NR3C2.