| 货号： | ONI-171389 |
| CAS号： | 1226895-20-0 |
| 供应商： | 美国 |
| 数量： | 888.0 |
| 英文名： | ATB346;ATB 346 |
| 保质期： | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
| 保存条件： | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
| 规格： | (5mg/100mg/438mg) |
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. IC50 value: Target: COX-2 ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but produced negligible damage in the stomach and intestine, Unlike naproxen and celecoxib, ATB-346 accelerated healing of pre-existing gastric ulcers. In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB-346 did not elevate blood pressure in hypertensive rats [1]. Treatement with ATB-346 exhibited a significantly more rapid and sustained recovery of motor function, achieving greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI [2].
温馨提示：不可用于临床治疗。
点击图片查看原图
份 库存999份
[VIP第1年] 指数:2
通过杭州市市场监督管理局认证 [诚信档案]
