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份 库存999份
| 货号： | IT1-H52W8 |
| 供应商： | ACROBiosystems |
| 英文名： | Human Integrin isoform alpha-7X2B beta 1 (ITGA7X2B&ITGB1) Heterodimer Protein |
| 保存条件： | -20 |
| 规格： | 100ug/1mg |
Less than 1.0 EU per μg by the LAL method.
纯度:
>90% as determined by SDS-PAGE.
活性:
产品背景:
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
产品描述:
Human ITGA7X2B & ITGB1 Heterodimer Protein, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.5 kDa (ITGA7X2B) and 83.7 kDa (ITGB1). Subunit ITGA7X2B is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The predicted N-terminus is Phe 34 (ITGA7X2B) & Gln 21 (ITGB1). As a result of glycosylation, the protein migrates as 110 kDa (ITGA7X2B) and 120-140 kDa (ITGB1) under reducing (R) condition, and 115-125 kDa and 125-135 kDa under non-reducing (NR) condition (SDS-PAGE).
SDS-PAGE
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