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份 库存999份
| 货号： | ab120321 |
| 英文名： | mGlu Agonists试剂盒 |
| 保存条件： | -20°C |
| 规格： | 1 kit |
概述
- 产品名称
mGlu Agonists试剂盒
参阅全部 Metabotropic glutamate receptor 试剂盒 - 特异性
A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006). *Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water. - 产品概述
A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006).*Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water.
Receptor
Description.
mGlu1,5
(S)-3,5-DHPG:
Selective group I mGlu agonist.
Suggested Solvent: Water
mGlu5
(R,S)-CHPG sodium salt:
Water soluble form of (R,S)-CHPG (ab120039), a selective mGlu5 agonist.
Suggested Solvent: Water
mGlu2,3
LY379268:
Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays > 80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
Suggested Solvent: Water
mGlu4,6,7,8 (group III)
L-AP4:
Selective group III mGlu receptor agonist.
Suggested Solvent: Water
mGlu4
VU0155041 sodium salt:
Water soluble, positive allosteric selective modulator at mGluR4 (EC50values are 798 nM and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease.
Suggested Solvent: Water
mGlu7
AMN082 dihydrochloride:
Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4, 5, 6 and 8 and ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.
Suggested Solvent: Water (5 mM) / DMSO (10 mM)
mGlu8
(S)-3,4-DCPG:
Potent, selective mGlu8a agonist (EC50 = 31 nM). Displays > 100-fold selectivity over mGlu7. Systemically active in vivo.
Suggested Solvent: Water
- 说明
KIT
性能
- 存放说明
Store at -20°C. Please refer to protocols.
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