CasPAses & Regulators: CasPAses: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR (CASPER), CRADD, CARD18, CARD17, MALT1, PYCARD, RFWD2 (COP1).
CasPAse Activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO (SMAC), EIF2AK3, F2, F2R, FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1, TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP.
CasPAse Inhibitors: BIRC5, CD27 (TNFRSF7), DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1, XIAP.
Anti-Apoptosis: Positive Regulation: BCL2L1 (BCL-X), BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1.
Negative Regulation: PIK3R2, RTN4, TNFAIP8.
Other genes: AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2, BIRC3, XIAP, BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2, CD27, CD40LG, CEBPB, CFDP1, CFL1, CFLAR, CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1, HBXIP, HTT, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1, HTATIP2, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, MALT1, MCL1, MKL1, MPO, MTL5, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA, PIM2, POGK, POLB, PRDX2, PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2 (PAI-2), SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP, TAX1BP1, TBX3, TGFB1, TIAF1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, TMX1, VEGFA, VHL, YWHAZ, ZC3HC1.
Induction of Apoptosis: Death domain receptors: BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B.
DNA damage: ABL1, AIFM1, BCL3, BRCA1, CHEK2 (RAD53), CIDEA, CIDEB,
DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN, TP53, TP73.
Oxidative stress: GPX1, PRODH, RNF7, TP53I3
Extracellular signals: ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR (CASPER), DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13, PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25.
Intracellular signals: CDKN1A, CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1.
Other genes: ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3, BCL10, BCL2L11, BCL2L13, BCLAF1, BIK, BNIP1, BNIP3, BNIP3L, BOK, CASP10, CASP3, CASP4, CASP6, CD2, CD27, CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO (SMAC), EI24, ERCC2, ERCC3 (XPB), ERN1, ERN2, FAS, FASLG, FEM1B, FOXL2, FOXO3, HRK, HTATIP2, IFNA2, IFNB1, IFNG, IKBKG, IKBIP, IL19, INHA, INHBA, JMY, LALBA, LCK, LTA, MAL, MAP3K10, MAPK1, MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1, PLG, PMAIP1, PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD, RPS3A, RUNX3, S100B, SAP30BP, SERINC3, SIPA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A, TNFRSF19, TNFRSF9, TNFSF10, TNFSF14, TNFSF8, TP53BP2, TP63, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443. TNF Domain: EDA, FASLG (TNFSF6), LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8. TNFR Domain: CD27 (TNFRSF7), CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF6B, TNFRSF8, TNFRSF9.
BCL2 and BAG Domain: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1.
BIR Domain: BIRC2 (c-IAP2), BIRC3 (c-IAP3), BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1), XIAP.
CARD Domain: APAF1, BCL10, BIRC2 (c-IAP2), BIRC3 (c-IAP1), CARD10, CARD11, CARD14, CARD6, CARD9, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, CARD18, CARD17, NLRP1, NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2.
DEATH Domain: CRADD, DAPK1, EDAR, FADD, PIDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD.
TRAF Domain: TRAF2, TRAF3, TRAF5, TRAF7.
Other Regulators of Apoptosis: BCL6, CEBPG, DBP, DDIT3 (GADD153/CHOP), GRM4, LGALS1, MADD, MAPK8, NKX3-2, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1, TDGF1, TRAF6, ZAK.