点击图片查看原图
份 库存999份
| 货号： | K1197 |
| 供应商： | 上海高创 |
| 保存条件： | - 20℃ |
| 保质期： | 2年 |
| CAS号： | 376348-65-1 |
| 英文名： | Maraviroc（Targets：MIP-1alpha,MIP-1beta,RANTES） |
| 规格： | 2mg |
Information
| SKU:K1197 | M. Wt:513.67 | ||
| Formula:C29H41F2N5O | Solubility:DSMO 103 mg/mL Water <1 mg/ml Ethanol 103 mg/mL | ||
| Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
| CAS No.:376348-65-1 | |||
| Chemical Name4,4-difluoro-N-((S)-3-(3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-aza-bicyclo[3.2.1]octan-8-yl)-1- phenylpropyl)cyclohexanecarboxamide | |||
| Description | As a CCR5 inhibitor, Maraviroc (Selzentry, UK-427857, Celsentri) can inhibit MIP-1alpha, MIP-1beta and RANTES with IC50 of 3.3 nM, 7.2 nM and 5.2 nM. | |||||
| Targets | MIP-1alpha | MIP-1beta | RANTES | |||
| IC50 | 3.3 nM | 7.2 nM | 5.2 nM | |||
| In vitro | As a selective CCR5 inhibitor, Maraviroc (UK-427,857) shows potent anti-human immunodeficiency virus type 1 (HIV-1) activity, including 43 primary isolates from various clades and diverse geographic origin. Maraviroc does not show any in vitro cytotoxicity. [1] By blocking CCR5, Maraviroc (UK-427,857) can keep HIV from entering into CD4+ lymphocytes. [2] | |||||
| IN vivo | The half-life values of Maraviroc are 0.9 hour in the rat and 2.3 hours in the dog. Following oral administration (2 mg/kg) to the dog, the Cmax (256 ng/ml) occurred 1.5 hours post-dose, and the bioavailability is 40%. | |||||
温馨提示：不可用于临床治疗。
[VIP第1年] 指数:2
通过金山区市场监管局认证 
