InVivoMAb anti-mouse PD-L1 (B7-H1)_抗体制备_免疫学服务_技术服务库_商城

货号：	BE0101
抗体英文名：	InVivoMAb anti-mouse PD-L1 (B7-H1)
靶点：	PD-L1
应用范围：	in vivo PD-L1 blockade Immunofluorescence Immunohistochemistry (frozen) Flow cytometry Western blot
克隆性：	是
保存条件：	Undiluted at 4C in the dark.
亚型：	IgG
规格：	25MG

The 10F.9G2 monoclonal antibody reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and PD-1. The 10F.9G2 antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).

温馨提示：不可用于临床治疗。

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InVivoMAb anti-mouse PD-L1 (B7-H1)

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