【medical-news】天然蛋白可抑制小鼠致死性脑癌..._其它天然蛋白_天然蛋白_蛋白类_知道

Natural Protein Stops Deadly Human Brain Cancer In Mice

Scientists from Johns Hopkins and from the University of Milan have effectively proven that they can inhibit lethal human brain cancers in mice using a protein that selectively induces positive changes in the activity of cells that behave like cancer stem cells. The report is published in Nature.
来自约翰霍普金斯和米兰大学的科学家，有效地证明了他们可使用一种蛋白质，在小鼠身上抑制致死性人的脑癌，这种蛋白质选择性地在表现为癌干细胞特性的细胞中引起阳性改变。
The most common type of brain cancer-glioblastoma-is marked by the presence of these stem-cell-like brain cells, which, instead of triggering the replacement of damaged cells, form cancer tissue. Stem cells, unlike all other cells in the body, are capable of forming almost any kind of cell when the right "signals" trigger their development.
最常见的类型的脑癌即恶性胶质瘤以出现类似癌干细胞的脑细胞为特征，这些细胞不是替代损伤细胞，而是形成肿瘤。干细胞不象身体内的其他细胞，当信号触发它的进化时，它可形成任何种类的细胞。
For their treatment experiment, the researchers relied on a class of proteins, bones, that cause neural stem-cell-like clusters to lose their stem cell properties, which in turn stops their ability to divide.
研究者使用一类蛋白质-骨形态发生蛋白用于他们的治疗实验。该蛋白引起神经干细胞样细胞丢失它们干细胞特性，继而阻止它们分裂的能力。

First they pretreated human glioblastoma cells with bone morphogenic protein 4 (BMP4), then injected these treated cells into mouse brains. In mice injected with cells that were not pretreated, large, invasive cancers grew. In the mice with BMP4-treated cells, no cancers grew at all. Three to four months after injection, all mice that got untreated cells died, and nearly all mice with BMP4-treated cells were alive.
首先他们用骨形态发生蛋白4 (BMP4)预处理人恶性胶质瘤细胞，然后把这些处理细胞注射到小鼠脑内。注射没有预处理细胞的小鼠脑内，可见大的浸润性的癌肿生长，而使用BMP4处理的细胞的小鼠，根本就没有肿瘤生长。注射后3-4个月，注射没有处理细胞的小鼠全部死亡，而注射BMP4处理细胞的小鼠几乎全部存活。
Next, the scientists delivered slow-release BMP4-containing "beads" directly into mouse brains with implanted glioblastoma cells. Mice that got empty beads developed large malignant tumors and died. Mice with BMP4 beads survived much longer, and 80 percent survived four months after cancer cell implants.
接着，科学家将含有缓慢释放BMP4的粒子直接送达植入恶性胶质瘤细胞的小鼠脑内。注射空粒子的小鼠长出大的恶性肿瘤而死亡。注射BMP4粒子的小鼠生存时间长得多，癌细胞植入后，80%小鼠活到4个月。
"Our idea is to treat patients with BMP4 or something like it right after surgery to remove glioblastoma in hopes of preventing the regrowth of the cancer and improving survival time," says Alessandro Olivi, M.D., director of the Division of Neurosurgical Oncology at Hopkins and a contributor to the study.
“我们的想法是，手术切除恶性胶质瘤后，使用BMP4或其它什么的治疗患者，希望预防癌肿的复发，延长患者的生存期” 霍普金斯肿瘤神经外科主任，该研究作者Alessandro Olivi博士说。
Olivi says clinical studies using BMP4 could begin within a year and, if successful, drug therapies could be available to the public within three to four years.
Olivi博士说，使用BMP4的临床研究年内可以开始，如果成功，药物治疗3-4年内可以可以大众使用。
"This was proof of the idea that BMPs could stop glioblastoma by depleting the stem-cell-like population that feeds it," says Henry Brem, M.D., chairman of the Department of Neurosurgery at Hopkins and a collaborator in the study. "This opens exciting doors to future research into treatments and therapies for such a devastating disease."
“BMP可通过减少干细胞样细胞数量阻止恶性胶质瘤，该想法得到证明。它打开了治疗这些破坏性疾病进一步研究的令人兴奋的大门。” 霍普金斯肿瘤神经外科主席，该研究得合作者Henry Brem博士说。

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【medical-news】天然蛋白可抑制小鼠致死性脑癌...