【转贴】世界首例“带有抗猪瘟病毒基因的克隆猪”在吉林大学诞生..._克隆基因_克隆和表达_分子类_知道

赖良学博士，1984年毕业于四川某末流畜牧兽医学院，在美国密苏里大学动物中心实验室采用基因敲除技术首次实现了人类培育“基因敲除”克隆猪，科学界普遍认为“这是向异种器官移植迈出的关键一步”，为人类的器官移植开辟了新天地；其论文在《科学》杂志2002年第一期发表；从经济方面看，华尔街分析师估计，其市值每年为50—60亿美元。

2004-2006研究助理教授　美国密苏里大学国家猪资源保护与研究中心
2002-2004研究助理教授　美国密苏里大学动物研究中心
1998-2002博士后　美国密苏里大学动物研究中心
1997-1997副教授　中国人民解放军农牧大学
1995-1997博士后　中国人民解放军农牧大学军事兽医研究所转基因动物实验室
1990-1995讲师　中国人民解放军兽医大学动物解剖教研室
1987-1990助教　中国人民解放军兽医大学动物解剖教研室

发表文章：
Liangxue Lai, Donna Kolber-Simonds, Kang-Wook Park, Hee-Tae Cheong, Julia L. Greenstein, Gi-Sun Im, Melissa Samuel, Aaron Bonk, August Rieke, Bill N. Day, Clifton N. Murphy, David B.Carter, Robert J. Hawley, Randall S Prather. Production of α -1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning. Science 2002 295:1089-92
Donna Kolber-Simonds, Liangxue Lai (Equal contribution with first author), Steven R. Watt, Maria Denaro, Scott Arn, Monica L. Augenstein, Jeffery Betthauser, David B. Carter, Julia L. Greenstein, Yanhong Hao, Gi-Sun Im,Zhonghua Liu, Greg D. Mell, Clifton N. Murphy, Kwang-Wook Park, August Rieke, David Ryan, David H. Sachs, Erik J. Forsberg, Randall S. Prather and Robert J. Hawley. α -1,3-galactosyltransferase null pigs via nuclear transfer with fibroblasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci U S A. 2004 11;101(19):7335-40
Liangxue Lai, Jing X. Kang , William T. Witt, Jingdong Wang, Hwan Yul Yong, Yanhong Hao, David M. Wax, Rongfeng Li, Rhobert W. Evans, Thomas E. Starzl, Randall S. Prather, Yifan Dai Cloned Fat-1 Transgenic Pigs Rich in Omega-3 fatty Acids, Nature biotechnology, Nat Biotechnol. 2006 24(4):435-436. 2006
Liangxue Lai, Kwang-Wook Park, Hee-Tae Cheong, Birgit Kühholzer, Melissa Samuel, Aaron Bonk, Gi-Sun Im, August Rieke, Billy N. Day, Clifton N. Murphy, David B. Carter, Randall S. Prather. A transgenic pig expressing the enhanced green fluorescent protein produced by nuclear transfer using colchicines-treated fibroblasts as donor cells. Molecular Reproduction and Development, 2002 62:300-306.
Liangxue Lai, Tao Tao, Zoltan Machaty, Birgit Kuhholzer, Qing-Yuan Sun, Kwang-Wook Park, Bill N Day, Randall S Prather. Feasibility of producing porcine nuclear transfer embryos by using G2/M-stage fetal fibroblasts as donors. Biology of Reproduction. 2001 65:1558-64.

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【转贴】世界首例“带有抗猪瘟病毒基因的克隆猪”在吉林大学诞生...